Pharmaceutical High shear mixer granulator wet granulation

1. Work principle of high shear mixer granulator

The materials are fed into the container by manual feeding or vacuum feeder. Then the materials are mixed and added with adhesive, and then move in circular, radial and axial directions under the action of the modified agitator. They are fully mixed, and then cut into spherical particles with uniform and dense texture by the granulating cutter. (The following schematic diagram).

2. Application of high shear mixer granulator

High shear mixer granulator is widely used in the process of material mixing and granulation in pharmaceutical, food, chemical, pesticide and other industries. The granules are conducive to tablet pressing and capsule filling.

3. Main structure of high shear mixer granulator

3.1. Equipment composition of high shear mixer granulator

This machine is mainly composed of a machine frame, a container with a cover, a mixing system, a cutting system, a discharging device, a control system, a water and gas system, etc.

3.2. Machine frame of high shear mixer granulator

It is welded by section steel, and the frame is covered with stainless steel plate. The chassis frame is divided into upper and lower parts. The bottom is equipped with adjustable support feet and shock absorption sizing blocks. The upper frame supports the container with cover, mixing system, cutting system, and discharge device. The lower frame mainly carries the reducer, motor, and transmission system. The electrical control main board is placed in the lower frame. The frame material is Q235-A. The three sides are equipped with a protective cover plate, and the other side is equipped with a movable door made of a protective cover plate. The material is SUS304.

3.3. Container with cover of high shear mixer granulator

The container is an inverted cone, the bottom center is equipped with an agitator, the side is equipped with a granulating cutter, and the upper part is equipped with a quick opening cover; The quick opening cover is composed of a cover, a cover opening fixed arm, a cover opening rotating arm, an air cylinder, etc. The cover is provided with a feeding port, a sight glass, and an air vent. Material of container is SUS304 or SUS316L.

3.4. Mixing system of high shear mixer granulator

Mixing system: it is composed of motor, reducer, transmission shaft, mixing blades, compressed gas seal device and a rotary air gap seal. The material is 45# steel and SUS304. (Or SUS316L)

3.5. Cutting device of high shear mixer granulator

It consists of motor, transmission parts, multiple U-shaped cutters, and air sealing components, etc.

3.6. Discharging system of high shear mixer granulator

It consists of discharge seat, discharge plug, discharge port, guide rod and air cylinder, etc.

3.7. Control system of high shear mixer granulator

It consists of PLC, touch screen, inverter, electrical components, pneumatic components.

4. Features of high shear mixer granulator

1. The inverted cone type pot body is used to increase the number of material turning during the mixing process, and the mixing efficiency is high and the speed is fast.

2. The PLC microcomputer program is used to compile the control system loop, and the human-computer interface and screen display the process flow operation, which is operable; Variable operating parameters can be automatically tracked and adjusted by fuzzy technology; The frequency converter can be used to adjust the mixing speed stably and safely to ensure the granulation effect, and the granulation size can be adjusted at will. The system is highly automated and easy to operate.

3. The mixing agitator with unique structure was designed by 3D CAD research, which is conducive to scraping the attachment on the inner wall of the container, reducing the material deposition on the inner wall and bottom, and the collision of particles on the inner wall, improving the granulation efficiency and ball rate, and reducing the content of fine powder.

4. Equipped with spray device or drip device. The method of spray, drip or direct mixing can be adopted according to the different requirements of different materials when adding the adhesive. The amount of adhesive is saved and the mixing granulation effect is good.

5. The seal of mixing agitator shaft adopts double compound technology of rubber ring oiling and spiral airing, which completely solves various faults and problems of shaft seal during mixing granulation.

6. Equipped with vacuum feeding mechanism, it can realize automatic and dust-free operation.

7. The pot cover of the wet granulating machine adopts the side opening technology, and can automatically lift, which is convenient for operation and high in safety.

8. Both mixing and cutting are equipped with frequency conversion speed regulation function to achieve the best granulation effect and ensure that the requirements for slow and uniform discharge of the swing granulator under the high-level machine are met.

5. Parameters of high shear mixer granulator