ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE Used For Sitafloxacin CAS 101987-86-4

Name: ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE Used For Sitafloxacin CAS 101987-86-4
Brand: Taizhou Volsen Chemical Co., Ltd.
Rating: 4.3 (12 reviews)

$1.00 ~ $1.00 / Gram

Send Inquiry

Model No. :	101987-86-4
Brand Name :	VOLSENCHEM

10yrs

Taizhou, Zhejiang, China

Manufacturer
OEM service

Visit The Store

Gold Supplier
Platform Certification
Online Expo

Taizhou Volsen Chemical Co., Ltd.

VISIT THE STORE

You might also like

Isavuconazole side chain CAS 338990-31-1

Abrocitinib Development Code PF-04965842 CAS NO 1622902-68-4

High Purity Tedizolid Phosphate Intermediates CAS 1220910-89-3

Intermediate Of Tedizolid Phosphate CAS Number 1056039-83-8

Custom Synthesis For 4-Bromo-3-Fluoroaniline CAS 656-65-5

An Oroxazolidinone Antibiotic Drug Tedizolid 856866-72-3

2-(2-Methyl-2H-Tetrazol-5-Yl)Pyridine-5-Boronic Acid Pinacol Ester 1056039-83-8

(R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE 149524 -42-5

(5R)-3-(3-FLUORO-4-IODOPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE CAS 487041-08-7

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE Used For Sitafloxacin CAS 101987-86-4

$1.00

Product description

Sitafloxacin intermediate ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE CAS number is 101987-86-4, his synthetic process is as follows:
1.500ml four-necked flask was added 21g of 3-chloro-2,4,5-trifluorobenzoic acid, 210ml of dichloromethane and 1ml of DMF, stirred until dissolved, cooled to 0-10 ° C, and 13.1g of chloride was slowly added dropwise. Sulfoxide, after the dropwise addition, transfer to room temperature for 3h, dichloromethane was distilled off at 55-60 ° C under normal pressure, and then excess sulfoxide was distilled off under reduced pressure to obtain 3-chloro-2,4,5-tri Fluorobenzoyl chloride, 100 ml of dichloromethane distilled off was added to the reaction bottle, and stirred to prepare a solution for use.
Add 23.4g of ethyl 3-bromo-2-ethoxyacrylate and 100ml of dichloromethane to a 500ml reaction bottle, stir well, cool to 0-10 ° C, add 6.8g zinc powder, stir for 0.5h, and slowly add 3- Chloro-2,4,5-trifluorobenzoyl chloride solution. After the dropwise addition, transfer to room temperature for 2h, filter, add 100ml of water to the filtrate, stir, stand, separate, separate the organic phase, and add anhydrous sulfuric acid. Sodium was dried and filtered. The filtrate was first recovered from methylene chloride at 55-60 ° C under normal pressure, and then concentrated under reduced pressure at 20-30 ° C to obtain 32.6 g of a slightly yellow liquid. This slightly yellow liquid was the Sitafloxacin intermediate 3 :ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE CAS number 101987-86-4.

Thera. Category:Antibiotic

Cas No.:101987-86-4

Synonyms:Ethyl 2-(3-chloro-2,4,5-trifluorobenzoyl)acetate;Ethyl 3-chloro-2,4,5-trifluorobenzoylacetate;Benzenepropanoic acid,3-chloro-2,4,5-trifluoro-b-oxo-, ethyl ester; ethyl beta-(3-chloro-2,4,5-trifluorophenyl)-beta-oxopropionate;3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoic acid;ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE

101987-86-4