Cabergoline

Cabergoline

Product name:Cabergoline

Synonyms:6-Allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide

Formula:(C6H9NO)n.(C4H6O2)m

Molecular weight:451.60

CAS number:81409-90-7

Appearance :White or almost white crystalline powder

Identification :IR; X-ray; HPLC.

Optical rotation :-77.0o ~ -83.0 o

Loss on drying :NMT 0.50%

Cabergoline Imp A :NMT 0.15%

Allyl amide :NMT 0.10%

Allyl DHLA :NMT 0.15%

Cabergoline oxide :NMT 0.10%

Other individual impurities : NMT 0.10%

Total impurities :NMT 0.50%

Dichloromethane :NMT 100ppm

Acetone :NMT 200ppm

Tert-butyl methyl ether :NMT 200ppm

Xylene :NMT 1500ppm

Heptane :NMT 1000ppm

Residue on ignition :NMT 0.10%

Heavy metals :NMT 20ppm

Particle size :90% of particle size NMT 80 µm

Bulk density :0.20 ~ 0.35g/cm3

Assay (HPLC) :98.0% ~ 102.0%(recalculated on anhydrous basis)

Standard: EP6.0,USP30