Spectinomycin Hcl Lincomycin Hcl Soluble Medicine

Spectinomycin Hydrochloride and Lincomycin Hydrochloride Soluble Powder

       Very Soluble Powder of Spectinomycin Hydrochloride and Lincomycin Hydrochloride

[Main Component]

Spectinomycin Hydrochloride and Lincomycin Hydrochloride

[Description]

This product is white to off-white powder.

[Pharmacological Action]

Pharmacology

Spectinomycin belongs to the class of aminoglycoside antibiotics, and has a moderate inhibitory effect on a variety of Gram-negative bacilli, such as E. coli, Salmonella, Shigella, and Proteus. It is sensitive to streptococcus, pneumococcus, staphylococcus epidermidis and certain mycoplasmas (such as Mycoplasma gallisepticum, Mycoplasma turkeyi, Mycoplasma synovialis, etc.). Mostly insensitive to Streptococcus aureus and Staphylococcus aureus. It is usually resistant to Pseudomonas aeruginosa and Treponema pallidum. Intestinal bacteria are more resistant to spectinomycin, but they do not exhibit cross-resistance with streptomycin. Lincomycin has good antibacterial activity against anaerobic bacteria, such as Clostridium, Peptococcus, Peptostreptococcus, Clostridium tetanus, Clostridium perfringens and most actinomycetes. Lincomycin mainly acts on the 50S subunit of bacterial ribosomes and affects protein synthesis by inhibiting the elongation of peptide chains.

Pharmacokinetics

Spectinomycin only absorbs 7% after oral administration, but maintains a higher concentration in the gastrointestinal tract. The tissue concentration of the drug is lower than the serum concentration. It is not easy to enter the cerebrospinal fluid or eyes, and the rate of binding to plasma proteins is not high. Most of the drug is discharged through glomerular filtration in its original form. Lincomycin is poorly absorbed internally and has a bioavailability of 30% to 40%. Mixed feeding can reduce its absorption speed and absorption. Chickens took 50 mg of this product per kilogram of body weight (dissolved in drinking water) for 7 days. The lincomycin in the plasma reached 0.14 µg / ml during the test period, and the concentration of spectinomycin was minimal. After 7 days of the test, Only exceed 0.1μg / ml.

[Pharmacological interaction]

(1) If used together with Lincomycin, it can significantly increase the antibacterial activity against Mycoplasma and expand the antibacterial spectrum.

(2) If Lincomycin used together with Anticholinesterase, and it might decrease the effect of latter one.

(3) If used together with Erythromycin, there might be Antagonism.

[Effect and function]

Antibiotics.  Treatment for Gram-negative bacteria, Gram-positive bacteria and Mycoplasma infection

[Usage and dosage]

Calculated based on this product.

Mixed in water: Every 1L water, 0.5~0.8g for 5~7 days old chicken, and continuous use for 3~5 days.

[Side effect]

According to the prescribed usage and dosage, no adverse reactions have been observed.  

[Notice]

Only used on 5~7 days old chicken.

[Withdrawal period]

0 day.

[Specification]

(1) 5g: 2g Spectinomycin and 1g Lincomycin (calculated on C₁₈H₃₄N₂O₆S)

(2) 50g: 20g Spectinomycin and 10g Lincomycin (calculated on C₁₈H₃₄N₂O₆S)

(3) 100g: 40g Spectinomycin and 20g Lincomycin (calculated on C₁₈H₃₄N₂O₆S)

[Package]

25kg/drum

[Storage]

Keep airtight and shading in a dry place at room temperature.

[Validity]

2 years.