GMP Florfenicol Florfenicol soluble powder for animal use

Description of Florfenicol Powder                  Rx

 Generic name :Florfenicol Powder
English name: Florfenicol powder
Chinese Pinyin :Fubennikao Fen
[Main ingredients] Florfenicol
[Properties] This product is white or white powder
[Pharmacological action] Pharmacodynamics Florfenicol is a broad-spectrum antibiotic of amide alcohols, which is an antibacterial agent. It plays a role in inhibiting the synthesis of bacterial proteins by combining with the 50S subunit of ribosomal. It has strong antibacterial activity against a variety of Gram-positive and Gram-negative bacteria. Pasteurella haemolyticus, Pasteurella multocida and Actinobacillus suis pleuropneumonia are highly sensitive to florfenicol. In vitro, florfenicol has similar or stronger antibacterial activity than sulfoxamycin against many microorganisms. Some bacteria resistant to amide alcohols due to acetylation, such as Escherichia coli and Klebsiella pneumoniae, may still be sensitive to florfenicol. It is mainly used for bacterial diseases caused by susceptible bacteria in pigs, chickens and fish. Such as Pasteurella haemolyticus, Pasteurella multocida and Actinobacillus suis pleuropneumonia caused by respiratory diseases in cattle and pigs. Typhoid fever and paratyphoid fever caused by Salmonella, chicken cholera, chicken dysentery, Escherichia coli disease, etc. Fish Pasteurella, Vibrio, Staphylococcus aureus, hydrophila, enteritis bacteria caused by fish bacterial septicemia, enteritis, erythroderma, etc.
Pharmacokinetics Florfenicol is rapidly absorbed by oral administration and therapeutic concentrations can be reached in the blood after approximately 1 hour. Peak plasma concentrations were reached within 1-3 hours. The bioavailability was more than 80%. Florfenicol is widely distributed in animals and can cross the blood-brain barrier. It is excreted mainly in its original form in the urine and to a lesser extent in the feces.
[Drug interactions] (1) Macrolides and lincosamines have the same target of action as this product, which are bound to the 50S subunit of bacterial ribosylation, and can produce antagonistic effects when combined.
(2) It may antagonize the bactericidal activity of penicillins or aminoglycosides, but it has not been demonstrated in animals.
 [ Action and use ] Amido alcohol antibiotics. They are used for Pasteurella and Escherichia coli infections.
 [ Usage and dosage ] Based on this product. For oral use; 0.2 ~ 0.3g/lkg body weight for pigs and chickens, twice a day for 3 ~ 5 days; Fish 0.1-0.15 g, once a day, for 3 to 5 days.
[Adverse reactions] This product has a certain immunosuppressive effect when it is used at a higher than the recommended dose.
[Precautions] (1) Chickens that produce eggs for human consumption. Shall not be used during the laying period.
(2) Use breeder chickens with embryo toxicity, and use livestock during pregnancy and lactation with caution.
(3) It is forbidden to use animals during vaccination or with severe immune deficiency.
(4) For animals with renal insufficiency, the dose should be appropriately reduced or the interval of administration should be prolonged.
[Off-drug period] 20 days for pigs, 5 days for chickens, and 375 degrees per day for fish.

[Rest period] chicken 7 days.
[Specifications] 10%
[Packaging]
[Storage] Closed, stored in dry place.