Advantages 1. Free samples are available. 2. GMP, ISO certificate. 3. Good water solubility. 4. Low content impurities. Product Overviews Product Name: Andrographis Paniculata Extract Latin Name: Andrographis paniculata (Burm. f.) Nees. Active Ingredient: Andrographolide, Dehydroandrographolide, Neoandrographolide Synonyms: Andrographis Paniculata P. E, Andrographis Paniculata Extract, Andrographolides Extract, Andrographis Paniculata, herba andrographitis extract , Kariyt extract Used Part: Whole herb
What is Andrographis paniculata? Andrographis paniculata (Burm.f.) Nees (Acanthaceae), a plant widely used as traditional herbal medicine in many countries, commonly known as ‘king of bitters,’ is an herb traditionally used in Ayurveda and Traditional Chinese Medicine. In traditional Chinese medicine, it is an important cold property herb used for antipyretic properties. And it is commonly used to prevent and treat the common cold. Traditionally the leaves are used as/in influenza, bronchitis, gonorrohea, cholera, fertility and antibacterial, anticancer, antidiabetic, anti-inflammatory and anti snake venom etc. What is Andrographolide? Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. Andrographolide is the most active and important compound of the plant.It is an extremely bitter substance extracted from the stem and leaves of A. Paniculata and it is used experimentally in different areas of research including cell signaling, immunomodulation, and stroke. What is Andrographis paniculata Extract? Extracts of the plant have been reported to exhibit a wide range of biological activities of therapeutic effects such as anti-inflammation, anti-cancer, immunomodulation, anti-infection, anti-hepato- toxicity, anti-atherosclerosis, anti-hyperglycemic effect and anti-oxidation. Many studies have been done in different countries in the world and found Andrographis paniculata was extremely nontoxic even in higher doses. Other names Kalmegh (Hindi), Kalmegha (Snaskrit), Chuanxinlian (Chinese), Kalupnath , Kirayat (Hindi), Mahatita (King of Bitters), Alui , Bhunimba , Bhui-neem , Yavatikta (Sanskrit), Sam biloto (Malay).
Function Anti-fertility In our country 3 studies have been done by Zoha et al with the doses of 2 gm/Kg body weight of sun dried Andrographis paniculata powder in both male & female mice everyday for 6 weeks. None of the animals were pregnant after mating. S Sakila et al. Relationship of anti-fertility effects of Andrographis paniculata and hormonal assay in female rats. BANGLADESH JOURNAL OF MEDICAL SCIENCE 2009, 8(1-2): 10-14. Anti-inflammatory The anti-inflammatory effect occurs because the dehydroandro-grapholides stimulate the production of ACTG in the hypophysis. The ACTG increases the synthesis and release of corticosteroids, which have an anti-inflammatory effect. Dehydroandro-grapholides have a direct inhibitor effect over NF-kapa beta-, which is an important transcriptional factor related to the inflammatory response. Immunomodulator Andrographis paniculata is a powerful stimulant for the immunologial system, through both the antigen specific and non specific way. It optimizes the expression of the genes that codify the cytokines’ receptors, and the synthesis of the histocompatibility molecules, type I and II; in this way, it improves the interaction between the competent cells. Anticarcinogen As it has been noted, malign cells appear when some cells do not respond to the signals that intend to limit their growth. When cells mature properly, they define their specialization in order to perform their respective functions. The carcinogenic cells are those that do not mature, and are similar to the embryonal cells. The more immature they are, the more aggressive the tumor will be. Scientist used Andrographis paniculata in a test done with mice. They discovered that the terpenes from the plant caused the differentiation in Leukemia cells, making them to be more mature, and therefore, less aggressive. The extract of Andrographis paniculata, as well as causing the differentiation in cancerous cells, is also cytotoxic to those cells. This was demonstrated when it acted against the Epidermidal Carcinoma cells of the skin as well as some Lymphocytic Leukemia cells. In 1977, a clinical research was done on 60 patients that were affected with Skin Basalioma, 41 of which had Metastasis. According to “The Journal of Chinese Medicine”, 12 patients, who just received extracts of Andrographis paniculata, recovered. In 1996, some tests showed that the extract blocked, in a very secure way, the development of Prostate Cancer, Breast Cancer and Non Hodgkin’s Lymphoma. The scientist, based on the results of the effect of Andrographis paniculata over breast cancer cells, considered that the extract probably inhibits the synthesis of DNA in the carcinogenic cells. Antiviral Andrographis paniculata is a powerful antiretroviral. All the viruses, including HIV, cannot reproduce without using the replication machinery of the cells. The HIV virus sticks to the cell, using CD4, CCR5 and CXCR4 molecules on its surface. The viruses tend to concentrate in the brain tissues and in the immunocompetent cells, which have those molecules, mainly CD4. When entering the cell, the viruses use a key enzyme to multiply themselves and this is called Reverse Transcriptase. The inhibitors of this enzyme are considered the most important agents used against AIDS; however, these drugs are very toxic. The alkaloids of Andrographis paniculata increase the action of the inhibitors over the Reverse Transcriptase, so that the dosage of the inhibitor drug can be reduced. Andrographis paniculata inhibits the cyclon-dependant kinases’ phosphorilation which is induced by the viruses so that the cellular cycle of the infected CD4 cells stops, as well as the viruse’s dissemination. The alkaloids of Andrographis paniculata also reduce the multiplication of the Hepatitis B, Herpes and Influenza viruses. Cardioprotective and antithrombotic Andrographolides reduce the procoagulant potential and improve the rheological properties of the blood. A research was done with rabbits that had an angioplasty. It was noticed that those who had received, orally, 3 days before and 4 weeks after the surgery, the Andrographis paniculata extract, showed, in 70% of the cases, stenosis of the Lymphatic Vessel. Those that did not receive the extract, in 100% of the cases, developed restenosis. It has been noticed that Andrographis paniculata reduce the size of the Myocardium in a very significative way. This is due to its capacity to activate the Fibrinolysis and to reduce the platalet’s aggregation. Andrographolides also exert a spasmolytic and beta-blocker effect. They help to reduce the arterial pressure and have a vessel-dilatator effect, because they increase the synthesis of the Nitric Oxide (NO) carried out by the endothelial cells. Application (1) Applied in pharmaceutical field, it is usually made into tablets, soft capsule, injectio, etc. to treat acute bacillary dysentery, gastroenteritis, cat fever, amygdalitis, faucitis, bronchitis, pneumonia, phthisis and so on. (2) Applied in veterinary field, it is made into pulvis to treat acute bacillary dysentery, gastro-enteritis and pneumonia of poultry and livestock. Packaging & Shipping
Shelf Life | 2 years if sealed and store away from direct sun light |
Packing | 25kgs/drum,double plastic-bag inside, aluminum foil bag or fiber drum outside. 1kg/bag, 5kg/bag, or 25kg/drum or Customized. |
Storage | Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat. |
Shpping | Shipment will be arranged in 3-5 workdays after payment received. |
Company Information
Hunan Zhengdi Biological Resources Development Co., Ltd. is a GMP manufacturer and we have provided high quality product and service to the plant extract industry of dietary supplements, functional foods/beverage, and pharmaceutical for more than 10 years. We concentrates on the high-efficient comprehensive development of plant resources and their deep-processing products. We are a manufacturer, a high-tech enterprise with enormous experience in research and development, as well as abundant plant resources. Our Management team has abundant pharmaceutical professional background, and main supervisory technical staffs have application and registration experiences of medical products and health-related products for ten years and can accurately grasp the requirements of policies, regulations and technical principles of medical products and health -related products.
Focusing on R&D and keep improving We have made a breakthrough on processing technology in order to meet the limits of microorganism and heavy metal content. We have experiences on R&D of medicine and health food for over 10 years, and our advantage are research on preparation technology, quality standard and study on general pharmacology & toxicology.
Outstanding advantages on controlling the resources We have own planting base of herbal medicines and cooperate with professional herbal medicine cultivation institutions. The cultivation is strictly according to the requirements of Chinese GAP standard. To ensure the raw material quality, harvest season, field processing, storage and transportation are also strictly controlled. Outstanding achievements on quality management Our company has built the GMP plant completely complying with Good Manufacture Practice in Hunan Zhanda Taikang Pharmaceutical Co., Ltd. and has the relevant Chinese drug GMP certificate. Production is strictly conducted according to Good Manufacture Practice. All the procedures are regulated by relevant GMP documents, from the purchase of raw material to sales of the finished product, to ensure the traceability of the whole production process in order to guarantee the product quality.
FAQ Q: Why order with Zhengdi? A: Zhengdi is a plant extract GMP manufacturer for nearly 10 years. We can supply special customized products for you with high quality. The most important is that we can provide technical help for you when you need to develop a new product. Q: How can i place orders if I’m not familiar with international imports? A: Zhengdi has skillful logistic tea for international shipment operations. We could supply FOB, CIF, door to door service (DDU/DDP terms) for your to some contries, it all depends. Q: Could clients get credit from Zhengdi? A: Zhengdi welcome repeat clients with good payment record to apply for credit. Please contact us for a credit application form. Q: Could Zhengdi provide us formula design assistance? A: YES, we do. Zhengdi not only supply Botanic/Plant extracts, but also we provide formula design services, contract manufacturing and natural ingredients applications solutions. Q: What is the Zhengdi products quality control system? A: According to ISO management system, all of our products must be tested during the produce process with production records. Moreover, all products must be tested again before delivery by Zhengdi lab to be sure of the product ptency and purity. Zhengdi lab is equipped with HPLC, UV-VIS and related instruments.