4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE Used For Ticagrelor CAS 145783-14-8

     The process of 4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE CAS 145783-14-8

1. Add 700g of 4,6-dihydroxy-2-mercaptopyrimidine to 10kg of water, add 5kg of 10% sodium hydroxide solution with stirring, control temperature <25 °C, add 5kg of methanol, 1.19kg of 1-brom after adding Propane, stir the reaction at 40 ~ 45 ° C overnight, cool to room temperature, add dilute hydrochloric acid to adjust the pH to 2 ~ 3, stir for 1 h, filtered, washed with water, dried at 45 ° C under reduced pressure to give 700 g 4,6-dihydroxy-2- Propylthiopyrimidine;

2. Add 910g of fuming nitric acid to 700g glacial acetic acid, cool down to 0~5 °C, add 700g of 4,6-dihydroxy-2-propylthiopyrimidine in batches, stir the reaction for 3h after adding, add water to crystallize, filter , washed with water, dried at 45 ° C under reduced pressure to give 728 g of 4,6-dihydroxy-5-nitro-2-propylthiopyrimidine;

3. Add 1.97kg of phosphorus pentachloride to 9.85kg of dichloromethane, cool down to -5~0 °C, and add 728g of 4,6-dihydroxy-5-nitro-2-propylthiopyrimidine in batches. After reacting for 2 h, 5 kg of saturated brine was added, and the mixture was separated, and the organic layer was evaporated to dryness to give 794 g of ticagrelor intermediate 4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE CAS 145783-14-8.

Thera. Category:Acute coronary syndromes treatment

Cas No.: 145783-14-8

Synonyms:4,6-Dichloro-5-nitro-2-(propythio)pyrimidine;4,6-Dichloro-5-nitro-2-propylthiopyridine;4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE;PyriMidine, 4,6-dichloro-5-nitro-2-(propylthio)-;4,6-dichloro-5-nitro-2-(propylsulfanyl)pyriMidine;4,6-dichloro-5-nitro-2-(propylsulfanyl)pyriMidine 4,6-dichloro-5-nitro-2-(propylsulfanyl)pyriMidine;

Molecular Formula: C7H7Cl2N3O2S

Molecular Weight: 

Assay: ≥99%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request