SITAFLOXACIN Intermediate 7 CAS 144282-37-1

Name: SITAFLOXACIN Intermediate 7 CAS 144282-37-1
Brand: Taizhou Volsen Chemical Co., Ltd.
Rating: 4.7 (39 reviews)

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Model No. :	144282-37-1
Brand Name :	VOLSENCHEM

10yrs

Taizhou, Zhejiang, China

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Product description

SITAFLOXACIN intermediate 7 has the chemical name of Carbamic acid, [(7S)-5-(phenylmethyl)-5-azaspiro[2.4]hept-7-yl]-, 1,1-dimethylethyl ester CAS number 144282-37-1, Synthetic method is as follows: First, ethyl acetoacetate is added to the kettle and then add DMF, 1,2-dibromoethane, potassium carbonate by turn, After the reaction overnight, then add water, then extracted with ethyl acetate, dried, concentrated, distilled to get the corresponding intermediates, and then adding ethanol in this intermediate, under ice bath drop Br2, to process the replace the reaction. After complete the drop, then stirred for 2 hours in greenhouse, added to 1.5 times the water to separate, and the lower layer was the product layer, which was concentrated to give the corresponding intermediate, then the corresponding intermediate under DEAD AND trialkylphosphine or triarylphosphine react with the (S)-7-tert-Butoxycarbonylamino-5-azaspiro[2.4]heptane to obtain a compound containing an azide group, and then reducing the azide group to the primary amine group, and then linking the primary amine group to the BOC protecting group to obtain the final target Product of SITAFLOXACIN intermediate 7 CAS number 144282-37-1. The chiral purity of SITAFLOXACIN intermediate 7 obtained by this synthetic method was more than 99.8%, avoiding unnecessary waste of the material.

Thera. Category: Antibacterial

Cas No.: 144282-37-1

Synonyms: CarbaMic acid, N-[(7S)-5-(phenylMethyl)-5-azaspiro[2.4]hept-7-yl]-, 1,1-diMethylethyl ester;(S)-tert-Butyl (5-benzyl-5-azaspiro[2.4]heptan-7-yl)carbaMate;[(7S)-5-(Phenylmethyl)-5-azaspiro[2.4]hept-7-yl]carbamic;Carbamic acid, [(7S)-5-(phenylmethyl)-5-azaspiro[2.4]hept-7-yl]-, 1,1-dimethylethyl ester;[(7S)-5-(Phenylmethyl)-5-azaspiro[2.4]hept-7-yl]carbamic acid tert-butyl ester;

NW: 302.41124

144282-37-1