Selective Inhibitor Of Cyclooxygenase-2 Parecoxib Sodium CAS 198470-85-8

Parecoxib sodium cas number is 198470-85-8 , which is an inactive prodrug of Valdecoxib that is readily soluble in water, is clinically used in the dose range for selective cyclooxygenase-2 (COX- 2) Inhibitors for intravenous and intramuscular injection)., often used for short-term treatment of postoperative pain, acute pain after moderate or severe surgery, the analgesic effect has been confirmed in postoperative treatment of stomatology, orthopedics, gynecology, etc. The medicine can also reduce the amount of mor phine and improve the quality of postoperative analgesia.

Parecoxib sodium cas number 198470-85-8 is a new type of non-steroidal anti-inflammatory analgesic (NSAID) marketed by Pfizer Inc., which can be rapidly hydrolyzed into valdecoxib by intravenous carboxylesterase after intravenous injection. Inhibition of cyclooxygenase-2 (COX-2) blocks arachidonic acid synthesis of prostaglandins and exerts anti-inflammatory and analgesic effects. Its inhibitory effect on COX-2 is 28,000 times that of cyclooxygenase-1 (COX-1). Due to its selective inhibition of COX-2, it has greatly reduced gastrointestinal side effects and has no adverse reactions of respiratory depression. It has been widely used for postoperative analgesia in recent years.