ROXATIDINE OXALATE CAS Number 110925-92-3

Name: ROXATIDINE OXALATE CAS Number 110925-92-3
Brand: Taizhou Volsen Chemical Co., Ltd.
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Model No. :	110925-92-3
Brand Name :	VOLSENCHEM

10yrs

Taizhou, Zhejiang, China

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Product description

ROXATIDINE OXALATE CAS number 110925-92-3. At present, most of its synthetic process with 3-Hydroxybenzaldehyde as the starting material, through three steps reaction, although the route is relative mature, but during the synthesis of second step to the third step, the reaction conditions is more than 180 ℃ high temperature, decompress to removal water, it not only require complex industrial equipment and huge energy consumption, but also hard to control the operation. It was raising the cost of production, and the production exists a large of flammable and explosive Security risks, over the years it has been plagued by the technical problems of manufacturing enterprises. There is a new synthetic ideas, we think it is worth learning, use 4-dimethylaminopyridine as a catalyst, dicyclohexylcarbodiimide as a dehydrating agent, The amide was formed with 3-piperidinyl methyl-phenoxypropylamine and glycolic acid reaction,then through filtration, washing and concentration to give ROXATIDINE OXALATE CAS number 110925-92-3. This method of synthesis in the efficient catalytic system and dehydration systems are often used to promote esterification and amidation reaction with a higher catalytic capacity, can significantly improve the yield, the reaction conditions are mild so that the reaction process is safe, the solvent selection range is wide, less waste.

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Cas No.:110925-92-3

Synonym:Roxatidine ethanedioate (2:1) (salt);N-[3-[3-(piperidinomethyl)phenoxy]-propyl]-hydroxyacetamide oxalate;ROXATIDINE OXALATE;Roxtidine oxalate;Roxatidine HeMioxalate;2-Hydroxy-N-[3-[3-(1-piperidinylMethyl)phenoxy]propyl]acetaMide Ethanedioate;2-hydro-N-[3-[3-(1-piperidinylMethyl)phenoxy]propyl]acetaMide ethanedioate (2︰1) (salt);2-Hydroxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide ethanedioate (2:1) (salt);

110925-92-3