Non-steroidal Intermediate 4-Biphenylacetic Acid CAS 5728-52-9

4-Biphenylacetic acid has the cas number of 5728-52-9,which is the main active ingredient of the non-steroidal anti-inflammatory drug  Biphenyl acetate gel has been marketed in more than a dozen countries. Mainly used for the treatment of deformed arthritis, frozen shoulder, tenosynovitis, periorbital inflammation, muscle pain, swelling of the wound, traumatic pain and other symptoms. In addition, 4-biphenylacetic acid is also an active metabolite of the anti-inflammatory analgesic fenbufen. Its anti-inflammatory and analgesic activity has been affirmed. The drug is well absorbed by the skin and has a good choice of "targeting" effect of the inflammation site.  The 4-biphenylacetic acid cas number 5728-52-9 is made into a gel for transdermal administration, so that the drug acts directly on the inflammation site of the human body without passing through systemic blood circulation, and can fully exert its anti-inflammatory and analgesic effects, and can avoid causing gastrointestinal disorders and the like adverse reactions.

    4-Biphenylacetic acid CAS number is 5728-52-9, It is a non-steroidal anti-inflammatory drugs, it can also be used for the synthesis of ethyl biphenyl ethyl acetate, biphenyl acetyl pyridine and other products can also be used for other fine chemical products, Nitrification products, hydrogenation products synthesis, use range is very wide. As a drug, 4-biphenylacetic acid is the active metabolite of fenbufen, the antiinflammatory activity is similar to fenfenfen. The main synthetic methods are as follows: 1. use Biphenyl as raw material, through chloromethylation, cyano substitution and acid hydrolysis to get it.  2. With 4-phenyl benzyl chloride as raw material, get by K4 [Fe (CN ) 6], Cu (OAc) 2, DMF cyanide substitution and acid hydrolysis. 3, use diphenyl chloroacetyl chloride as raw material, aluminium chloride as catalyst, chloroform dichloromethane or 1, 2-dichloroethane as the solvent,The reaction of 4-phenyl-a-chloro-acetophenone was obtained through the reaction of foukerification, and then the acetone was prepared by condensation reaction with new pentadiol in the catalysis of toluene sulfonic acid and then he and neopentyl glycol in p-toluenesulfonic acid catalyzed by condensation reaction by the ketal. Using the rearrangement reaction,through hydrolytic acidification to get 4-diphenylacetic acid CAS number 5728-52-9,The crude product is recrystallized from ethanol, ethyl acetate or 40 to 70% acetic acid to obtain 99.8% purity of 4-biphenylacetic acid. The biggest advantage of this synthesis method is that the raw materials are cheap and easy to obtain, the toxicity is small, the production will not produce new toxic compounds.

Thera. Category:  anti-inflammatory 

Cas No.:  5728-52-9

Synonym[1,1'-BIPHENYL]-4-ACETIC ACID;P-BIPHENYLACETIC ACID;:BIPHENYL-4-ACETIC ACID;FELBINAC;CI 83544;4-PHENYLPHENYLACETIC ACID;4-CARBOXYMETHYLBIPHENYL;4-BIPHENYLACETIC ACID;

Molecular Formula:C14H12O2

Molecular Weight :212.24

Pharmacopeia: in house spe.

Specifications: Available on request

Packing: Export worthy packing

Material Safety Data Sheet: Available on request