High Purity Daptomycin Powder CAS 103060-53-3

Product Name: Daptomycin

CAS: 103060-53-3

MF: C72H101N17O26

MW: 1620.67

EINECS:    600-389-2

Melting point:202-204?C

Boiling point :2078.2±65.0 °C

density :1.45±0.1 g/cm3

storage temp. :Sealed in dry

form :powder

color :colorless to faint yellow

What is Daptomycin

Daptomycin is the first entry of a new class of cyclic lipopeptide antibiotics that disrupts multiple aspects of bacterial membrane function including disruption of membrane potential and amino acid transport, inhibition of lipoteichoic acid synthesis and inhibition of peptidoglycan synthesis. It is indicated for the treatment of complicated skin and skinstructure infections (cSSSI) caused by a range of Gram-positive bacteria. This is distinct from previous classes of antibiotics that inhibit bacterial cell wall biosynthesis, bacterial DNA replication, and folate coenzyme biosynthesis. Due to this unique mechanism, cross-resistance has not been noted with any other class of antibiotics. It is produced by the fermentation of Streptomyces roseporus.

Daptomycin Function

Cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial.

 Daptomycin exhibits Ca-dependent depolarisation of the bacterial membrane resulting in loss of membrane potential leading to inhibition of DNA, RNA and protein synthesis which results in cell death.

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