eucommia bark extract

Alias: chlorogenic acid, tannic acid coffee

English name: Chlorogenic acid Chlorogenic acid

MDL: MFCD00003862 [1]

Material source: shaanxi huike Yang Xiaodong 132 * 9903 * 9903

Chemical name: 3 - coffee acyl quinic acid Cyclohexanecarboxylic acid, 3 - [[3 - (3, 4 - dihydroxyphenyl) - 1 - foxy - 2 - propenyl] foxy] 1, four, five - trihydroxy - 1, (1 s - (alpha 1 alpha, beta 3, 4, 5 alpha)]

System name: 1, 5-tetrafluorobenzoic four hydroxyl cyclohexane carboxylic acid - 2 hydroxy cinnamic acid ester) (3, 4 -

Product name: chlorogenic acid; (1 s, 3 r, 4 r, 5 r) - 3 - [[3 - (3, 4 - dihydroxy phenyl) - 1 - oxygen generation - 2 - allyl] oxygen] 1, four, five, three hydroxyl cyclohexane formic acid

CAS NO: 327-97-9

Login EINECS no. : 206-325-6

Molecular formula and molecular weight: C16H18O9 = 354.30

Edit this section plant sources

Mainly exist in honeysuckle, eucommia ulmoides leaves. Its products of honeysuckle extract of eucommia bark extract respectively

Rosaceae plant English hawthorn Crataegus oxyacantha Linn., fruit, willow food families willow plant food Lythrum salicaria l. flowers, no risk of child families slope plant willow Dodonaea viscose (l.) Jacp., polypodiaceae Eurasian plant keel water Polypodium vulgare l. rhizome, verbenaceae plants false sauce Stachytarpheta jamaicensis (l.) Vahl root, cruciferous vegetables cabbage Brassica oleracea L.v ar. Capitata l. stem and leaf, polygonaceae plants flat storage Polygonum aviculare l. all grass, rubiaceae plant food gatherer Galium verum l. all grass, caprifoliaceae plant purusha zhai Sambucus javanica Reinw. All the grass.

Physical traits edit this paragraph

Hemihydrate of needle crystal (water). 110 ℃ to anhydrous compounds, melting point 208 ℃, 24 d - [alpha] 35.2 ℃ (c = 2.8). 25 ℃ water solubility was 4%, the hot water solubility is bigger; Soluble in ethanol and acetone, slightly soluble in ethyl acetate. 13 CNMR (H2O) A: 126.6 (C - 1), 114.1 (C - 2), 144.2 (C - 3), 147.0 (C - 4), 116.0 (C - 5), 122.6 (C - 6), 145.9 (C - 7), 115.2 (C - 8), 168.9 (C - 9); B: 76.6-1 (C), 76.6 (C - 2), 70.6 (C - 3), 72.8 (C - 4), 71.0 (C - 5), 37.3 (C - 6), 180.1 (C - 7) [1].

Action and use edit this paragraph

Has broad antibacterial effect, but in the body can be inactivated proteins [11]. Like caffeic acid, oral or intraperitoneal injection can improve the rat central excitability. Can increase the intestinal peristalsis of mice and rats and rats uterus tension. Advantageous bravery effect, can improve the rat bile secretion [12-14]. White effect, to the person after inhalation plant dust containing this product, can happen asthma, dermatitis, etc., but after eating by intestinal secretions, become no allergenic substances (15th and 16th). Have a higher hemostatic, white blood cells [17]. And [18] the antiviral effect. The role of the blood clotting and bleeding time is shortened [19].

Toxicity is very small, in young rats oral LD50 is greater than 1 g/kg, intraperitoneal injection of greater than 0.25 g/kg [20].

(1) the antihypertensive effect: confirmed by clinical trials for many years, eucommia ulmoides chlorogenic acid has obvious antihypertensive effect, and smooth effect, non-toxic, no side effects. The university of Wisconsin (Sih Charles J, et al. The Separation and short of pinoresinol diglucoside moides olive J Am Chem Soc, 1976 16/32-bit (17) : 5412 study found that such as active ingredients of eucommia ulmoides green fall blood pressure is a loose ester alcohol two glucoside, peach leaf coral glucoside, chlorogenic acid, polysaccharide and eucommia ulmoides chlorogenic acid.

(2) the antineoplastic effect: modern pharmacological experiment proves that eucommia ulmoides chlorogenic acid has the efficacy of anticancer and suppressor, Japanese scholars study the variation of eucommia ulmoides chlorogenic acid original inhibition (antimutagenicity), found that the role and chlorogenic acid resistance variation, such as the original ingredients, reveals the significance of chlorogenic acid for tumor prevention.

(3) the kidney, strengthen the body's immune function: experimental table clearly eucommia ulmoides chlorogenic acid has excited pituitary - adrenal cortex system, enhance the effect of adrenal cortex function, shows that eucommia ulmoides chlorogenic acid as Yang kidney has a scientific basis. The study found that eucommia ulmoides chlorogenic acid can start the mononuclear macrophage system and abdominal macrophage phagocytosis activity, strengthen the body's nonspecific immune function, and can have inhibitory effect on delayed-type hypersensitivity.

(4) the anti-oxidation, anti-aging, musculoskeletal aging resistance: eucommia ulmoides chlorogenic acid contains a kind of can promote human body skin, bone, muscle protein synthesis and decomposition in the special ingredients, has the function of promoting metabolism, to prevent a recession can be used to prevent the astronauts caused by weightlessness of bone and muscle recession, also found that eucommia ulmoides chlorogenic acid both in vivo and in vitro have obvious antioxidative effect.

(5) the antibacterial, antiviral, eucommia ulmoides chlorogenic acid have stronger antibacterial anti-inflammatory effects, and coral glycosides of peach leaf polymer had obvious bacteriostasis, peach leaf coral glycosides yuan for gram negative and positive bacteria have inhibition. Peach leaf coral glycosides has bacteriostatic, diuretic effect, and can promote wound healing; Peach leaf coral glycosides with glycosidase after culture also can produce significant antiviral effect, but its itself off with antiviral function. Aichi, Japan medical university and confirmed by the research institute of medical science, alkaline substances extracted from eucommia ulmoides have the function of virus resistance to damage the body's immune system, this material may be used for the prevention and treatment of HIV/AIDS.

(6) other role: diuresis, cholagogue function, fall hematic fat, spuc

Pharmacological effects

[ chlorogenic acid pharmacology ]

(1) protect liver cholagogic effect

(2) the effect such as antibacterial, antiviral and spasmolysis

(3) on hyaluronidase and glucose - 6 - phosphatase inhibitory effect

(4) resisting mutagenesis

(5) on the removal of free radicals and lipid peroxidation

(6), kidney, strengthen the body's immune function

(7) anti-aging

(8) and musculoskeletal aging resistance

(9) antitumor effect

(10) analysis,

Introduction to edit this section structure and chlorogenic acid isomers

Chlorogenic acid, Chlorogenic acid, hereinafter referred to as "CA"), is made up of Caffeic acid (Caffeic acid) and Quinic acid, Quinic acid, gallic acid 1 - hydroxy six hydrogen) generated depside, is a plant of shikimic acid hitches in aerobic respiration process a styrene acrylic compounds.

According to the joint of the acyl coffee on quinic acid and number is different, in theory, a single coffee acyl acyl quinic acid, quinic acid and two coffee made up of a total of 10 chlorogenic acid isomers, respectively: 1 - coffee acyl acyl quinic acid, quinic acid, 3 - coffee, coffee acyl quinic acid, 4-5 - coffee acyl quinic acid, 1, 3 - coffee acyl quinic acid, 2, 1, 5-2 coffee acyl quinic acid, 1, 6 - coffee acyl quinic acid, 2, 3, 4-2 coffee acyl quinic acid, 3, 5 - two coffee acyl quinic acid, 4, 5 - two coffee acyl quinic acid. But so far, from plants found as follows: chlorogenic acid isomers of chlorogenic acid (3 - coffee acyl quinic acid), chlorogenic acid (Band510) (4 - coffee acyl quinic acid), green original acid (5 - coffee acyl quinic acid), A vision of chlorogenic acid (4, 5-2 coffee acyl quinic acid), chlorogenic acid B (3, 4-2 coffee acyl quinic acid), chlorogenic acid C (3, 5-2 coffee acyl quinic acid), lai ji (1, 3-2 coffee acyl quinic acid).

Edit this section of the biology

Chlorogenic acid is considered to be many medicines and proprietary Chinese medicine antibacterial, anti-inflammatory detoxification cholagogue main effective components, is usually as a qualitative or evendans