Bendamustine Methyl Butyrate CAS 115444-73-0

Bendamustine methyl butyrate CAS number is 115444-73-0, which is an important intermediate for the synthesis of bendamustine. His specific synthesis process is as follows: 51.6g 2-chloro-5-nitroaniline is added to a three-necked flask, 500ml of toluene is added, 36g of glutaric anhydride is added at room temperature, heated to 80℃ for 3 hours, cooled to room temperature, filtered, The filter cake was dried at 70℃ to give a 145gram yellow solid.
The yellow solid obtained above was added to 150 ml of a 40% aqueous solution of methylamine, and the mixture was heated to 50℃ for 3 hours, cooled to room temperature, adjusted to pH 4-5 with 2N hydrochloric acid to precipitate a yellow solid, stirred for 1 hour, filtered, The filter cake was rinsed with toluene and dried at 70℃ to give 40.5 g of pale yellow solid. This light yellow solid is a key step in the preparation ofBendamustine methyl butyrate CAS number 115444-73-0, The quality must be controlled and the next step can be carried out after obtaining a qualified product. The light yellow solid obtained above was added to a three-necked flask, and 365 ml of absolute ethanol was added thereto, and 12 ml of 98% concentrated sulfuric acid was added dropwise with stirring. After the completion of the dropwise addition, the mixture was heated to 80℃ for 3 hours, cooled to 45-50℃, and the reaction liquid was poured. A large amount of white solid was precipitated in 500 ml of a saturated aqueous solution of potassium carbonate, filtered, and the filter cake was washed with water until neutral, and dried at 70℃ to obtain a white powder of 40 mg of bendamustine methyl butyrate CAS  115444-73-0.

Thera. Category:Anti-allergen

Cas No.:115444-73-0

Synonyms:ASINEX-REAG BAS 13148082;4-(2-methyl-benzoimidazol-1-yl)-butanoic acid;TIMTEC-BB SBB011377;ZERENEX E/5046056;4-(2-METHYL-BENZOIMIDAZOL-1-YL)-BUTYRIC ACID;4-(2-METHYL-1H-BENZIMIDAZOL-1-YL)BUTANOIC ACID;

NW:218.25

M.W.:C12H14 N2 O2

Assay: ≥99%

Packing:Export worthy packing

Material Safety Data Sheet:Available on request