AP26113;AP-26113 (Brigatinib) CAS 1197953-54-0

Name: AP26113;AP-26113 (Brigatinib) CAS 1197953-54-0
Brand: Taizhou Volsen Chemical Co., Ltd.
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Model No. :	1197953-54-0
Brand Name :	VOLSENCHEM

10yrs

Taizhou, Zhejiang, China

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Product description

Brigatinib CAS number 1197953-54-0 referred to as AP26113, it is an inhibitor of lung cancer ALK target, is a non-small cell lung cancer targeted drugs. AP26113 is generally used after Crizotinib resistance, so in 2014 year the FDA awarded its tyrosine kinase inhibitor drug AP26113 orphan drug qualification for the treatment of methotrexate-resistant anaplastic lymphoma kinase Positive (ALK +) metastatic non-small cell lung cancer (NSCLC) patients. It has been shown that AP26113 inhibits at least 10 times more potency and selectivity than ALK bikazolidine , and that AP26113 is also effective for brain metastases in lung cancer.
Lung cancer ALK target is actually a small market, because the probability of lung cancer ALK mutation is not high, but crizotinib in this area is ALK inhibitor currently the only one listed , the effect is also very good, AP26113 CAS number 1197953-54-0 is the second Models, can be considered the second generation of ALK inhibitors, AP26113 is expected to break the monopoly position of crizotinib.
Thera. Category: Anti-cancer

Cas No.:1197953-54-0

Synonyms:5-Chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine;Brigatinib;AP26113 (Brigatinib);Brigatinib, AP26113;

AP26113

Molecular Formula:C29H39ClN7O2P

Molecular Weight: 584.10176

Purity: ≥98%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request

AP26113/brigatinib	1197953-54-0
2,5-dichloro-N-(2-(dimethylphosphoryl)phenyl)pyrimidin-4-amine	1197953-49-3
2-(diMethylphosphoryl)aniline	1197953-47-1
2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline	761440-75-9