Amoxicillin +Colistin Water Soluble Powder

The present invention relates to amoxicillin soluble powder and preparation method thereof.Amoxicillin soluble powder is made up of by weight following components: Utimox 10～60 parts, cosolvent 3～20 parts, stabilizer 3～30 parts, filler 0.4～85 parts, fluidizer 0.05～1 part；Wherein, stabilizer is sodium hexameta phosphate.Preparation method includes: raw material Utimox micronization, and cosolvent, stabilizer, filler and fluidizer pulverize and sieve respectively, material mix homogeneously, subpackage, inspection, obtains amoxicillin soluble powder finished product.Amoxicillin soluble powder of the present invention not only dissolubility is high, and good stability, can effectively suppress the hydrolysis of medicine, be beneficial to reality application.

COMPOSITION
Each 1 kg contains :
Amoxicillin base......100gm
Colistin base............400M.I.U

DESCRIPTION
The combination of amoxycillin and colistin acts additive.Amoxycillin is a semisynthetic broad-spectrum penicillin with a bactericidal action against both Gram-positive and Gram-negative bacteria.
The range of effect includes Campylobacter,Clostridium,Corynebacterium,E.coli,Erysipelothrix,
Haemophilus,Pasteriurella,Salmonella,penicilliase negative Staphylococcus and Streptococcus,spp.The bactericidal action is due to inhibation of cell wall synthesis. Amoxycillin is mainly excreted in urine.A major part can also be excreted in bile.Colistin is a antibiotic from a group of polymyxins with a bactericidal action against Gram-positive bacteria like E.coli,Haemophilus and Salmonella. Since colistin is absorbed for a very small part after oral administration only gastrointestinal indications are relevant.

INDICATIONS
Gastrointestinal,respiratory and urinary tract infections caused by amoxycillin and colistin sensitive-organisms,like Campylobacter,Clostridium,Corynebacterium,E.coli,Erysipelothrix,Haemophilus,Pasteriurella,Salmonella,penicilliase negative Staphylococcus and Streptococcus,spp..in calves,goats,poultry sheep and swine.

DOSAGE &ADMINISTRATION
For oral administration,it can be used via Feed or Drinking Water as below dosages.
Poultry:
For prevention :1gm per1 litre of drinking water 3 to 5days continuously.
For treatment:1gm per1 litre of drinking water 3 to 5days continuously.
Calves,Goats and Sheep:
5 gm per body weight two times daily for 3to 5 days either mixed with feed or put in the drinking water.
Swines(Pig):
2 to 4 gm per kg body weight ,two times daily,either mixed with feed or put in the drinking water.

STORAGE:
Store tightly , Keep in a cool and dry place, away from direct sunlight.