4-Bromocrotonic Acid For Making Afatinib CAS 13991-36-1

Name: 4-Bromocrotonic Acid For Making Afatinib CAS 13991-36-1
Brand: Taizhou Volsen Chemical Co., Ltd.
Rating: 4.7 (14 reviews)

$2000.00 ~ $2000.00 / Kilogram

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Model No. :	13991-36-1
Brand Name :	VOLSENCHEM

10yrs

Taizhou, Zhejiang, China

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Product description

Afatinib intermediate 4 as known as 4-Bromocrotonic acid CAS number is 13991-36-1, appearance is white solid. in actual production of afatinib,almost no manufacturers use 4-bromocrotonate acid in the route method. Once in a patent literature record one step of amidation reaction of synthesis afatinib which use 4- bromocrotonic acid as raw material,but the reaction yield is very low, maximum only reach 50%, and there was no manufacturer who commercial on production of 4-bromocrotonate acid CAS 13991-36-1, causing difficulties in raw material procurement, so this method was not suitable at that time. Through our effort, we realize our mass production, and make effective exploration of the patent, we think it is a lot of room for improvement. For the customer who has the intention of purchasing 4- bromocrotonate acid for the synthesis of afatinib, we will discuss a method without reservation aspects of the afatinib experience.

Thera. Category:Anti- cancer

Cas No.: 13991-36-1

Synonym:(E)-4-Bromo-2-butenoic acid;(E)-4-Bromocrotonic acid;2-Butenoic acid,4-broMo-, (2E)-;r-bromocrotonic acid;TRANS-4-BROMO-2-BUTENOIC ACID;2-Butenoic acid, 4-bromo-, (E)-;4-BroMobut-2-enoic acid;(2E)-4-Bromo-2-butenoic acid;

Molecular Formula: C4H5BrO2